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Our recent work on the enantioselective hydrophosphorylation of alkynes has been recognized as a "Hot Paper" by the editors of Angewandte Chemie and ranked among the "Most Accessed Papers" in October 2024.[Read more...]
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Compounds bearing both boryl and amino groups at distal positions are invaluable synthons for synthesizing pharmaceuticals, drug candidates, and natural products, but their catalytic enantioselective synthesis remains rarely explored. We developed an enantioselective 1,4-borylamination reaction through a copper-catalyzed cascade hydroborylation and hydroamination of arylidenecyclopropanes. This...[Read more...] -
The enantioselective addition of H-P(O)R1R2 to alkynes (hydrophosphorylation) offers a direct and efficient pathway to P-chiral compounds; however, the enantioselective hydrophosphorylation of unactivated alkynes remains a significant challenge, typically relying on noble palladium catalysts and proceeding via a kinetic resolution mechanism with less than 50% conversion. To address these limita...[Read more...] -
Vicinal stereogenic centers are ubiquitous structural scaffolds in both natural products and synthetic compounds, yet their enantioselective construction remains a significant challenge in organic synthesis. Transition-metal-catalyzed asymmetric borylative functionalizations of internal alkenes offer a promising strategy for the enantioselective installation of two adjacent chiral centers acros...[Read more...] -
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