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The enantioselective addition of H-P(O)R1R2 to alkynes (hydrophosphorylation) offers a direct and efficient pathway to P-chiral compounds; however, the enantioselective hydrophosphorylation of unactivated alkynes remains a significant challenge, typically relying on noble palladium catalysts and proceeding via a kinetic resolution mechanism with less than 50% conversion. To address these limita...[Read more...] -
Vicinal stereogenic centers are ubiquitous structural scaffolds in both natural products and synthetic compounds, yet their enantioselective construction remains a significant challenge in organic synthesis. Transition-metal-catalyzed asymmetric borylative functionalizations of internal alkenes offer a promising strategy for the enantioselective installation of two adjacent chiral centers acros...[Read more...] -
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