Vicinal stereogenic centers are ubiquitous structural scaffolds in both natural products and synthetic compounds, yet their enantioselective construction remains a significant challenge in organic synthesis. Transition-metal-catalyzed asymmetric borylative functionalizations of internal alkenes offer a promising strategy for the enantioselective installation of two adjacent chiral centers across carbon-carbon bonds. By leveraging the versatile transformations of the newly introduced boryl unit, this approach holds great potential for expanding the structural diversity of vicinal stereogenic scaffolds. In this review paper, we highlighted recent advancements in enantioselective borylative functionalizations of internal alkenes, underscored their utility, and discussed unsolved challenges and future directions in this field.

Thank you, Yushen, Haotian, and Jiaxin, for your tremendous efforts in making this possible—congratulations to all of you!