The enantioselective addition of H-P(O)R1R2 to alkynes (hydrophosphorylation) offers a direct and efficient pathway to P-chiral compounds; however, the enantioselective hydrophosphorylation of unactivated alkynes remains a significant challenge, typically relying on noble palladium catalysts and proceeding via a kinetic resolution mechanism with less than 50% conversion. To address these limitations, we recently achieved earth-abundant copper-catalyzed dynamic kinetic asymmetric hydrophosphorylation of alkynes, using a newly designed chiral 1,2-diamine ligand. This reaction is compatible with both aromatic and aliphatic terminal alkynes, yielding products with high yields (up to 95%), exclusive cis selectivity, and exceptional regio- and enantioselectivity (over 20:1 r.r. and up to 96% ee).

Thank you, Jie, Kang, Si-Mu, and Wen-Jun, for your excellent work! Congratulations to all of you!